But we have heard the fear that HIV could mutate into an infectious rather than contagious disease, or combine to form a killer combination with some other virus.
Two diseases have always been watched with caution as potential HIV disaster catalysts: Ebola and Tuberculosis.
So it is with great alarm that medical experts noted two critical alerts in KwaZulu-Natal this week:
Deadly new TB 'must be stopped'
The extreme drug-resistant tuberculosis (XDR-TB) in KwaZulu-Natal must be dealt with urgently, said international health experts here on Thursday.
"There is no time to wait before we embark on decisive action," said the World Health Organisation's Dr Ernesto Jaramillo, explaining that an epidemic could have a "deadly impact".
"It's imperative that we don't allow this to go unmitigated," said Dr Ken Castro, of the United States Centre for Disease Control.
"The emergence of XDR-TB poses a threat everywhere in the world."
More than 100 medical experts and policy-makers from around the world were meeting to discuss the XDR-TB which emerged in KZN recently.
Fifty-three cases were identified and 52 of the patients have died. The HIV/TB co-infection rate was high.
KZN's shocking HIV rates
Medical researchers are finding "unbelievable" rates of HIV and Aids infection among women in several parts of KwaZulu-Natal, with provincial prevalence levels varying between 38 and 50 percent.
Professor Gita Ramjee, of the Medical Research Council in Durban, said that in one area of the South Coast the HIV prevalence level in women was as high at 70 percent, while in the Embo area near Botha's Hill researchers found a prevalence level of more than 66 percent.